| Actors: | Dylan Baker, Louis Lombardi, Phil LaMarr, Elizabeth Banks, Vanessa Ferlito, Joanne Baron, Scott Spiegel, J.K. Simmons, Willem Dafoe, Aasif Mandvi, Dan Callahan, John Thurner, Kirsten Dunst, Brent Briscoe, Alfred Molina, Vince Cupone, James Franco, Phillip Gramm, Marc John Jefferies, Ted Raimi, Daniel Dae Kim, Tobey Maguire, Donna Murphy, Rachelle Roderick, Christine Estabrook, Bruce Campbell, Sam Raimi, Bill Nunn, Elya Baskin, Frank Bonsangue, Brendan Patrick Connor, Cliff Robertson, Rosemary Harris, Mageina Tovah, Emily Deschanel, Joy Bryant, Reed Diamond, John Landis, Anne Betancourt, Bill E. Rogers, Tom Carey, Brianna Brown Garrett Warren Bonnie Somerville |
Peter Parker is beset with troubles in his failing personal life as he battles a brilliant scientist named Doctor Otto Octavius, who becomes Doctor Octopus (aka Doc Ock), after an accident causes him to bond psychically with mechanical tentacles that do his bidding.